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Descrição
Indocyanine green (ICG) is a water soluble anionic tricarbocyanine dye which has been widely used for biological applications. (1) The photodegradation kinetics and aggregation of ICG were studied in aqueous solution by absorbance spectrum measurements. Air-saturated and N2-bubbled solutions of ICG in PBS and distilled water were investigated. Two excitation wavelengths were used, 780 and 808 nm. The photodegradation analysis was performed based on the number of absorbed photons and rate equations of the electronic excited states. The aggregation effect is influenced by the diluent medium and also a third emission band at 640 nm, associated with PBS solution, could be observed. This new emission band is associated to a trimeric band, when ICG is diluted in PBS. ICG in the lack of oxygen degradated, suggesting that oxygen is not the only pathway of degradation.(2)The degradation of the solution with aggregated forms does not follow the Beer-Lambert law. (3) The exposure to light increases the degradation rates. The photodegradation rates were distinct between the two excitation wavelengths.
Referências
1 DI NEZZA, F. et al. Thermodynamic properties and photodegradation kinetics of indocyanine green in aqueous solution. Dyes and Pigments, v.13,p. 342-347,2016.
2 ABELS,C. et al. Indocyanine green (ICG) and laser irradiation induce photooxidation. Archives of Dermatological Research, v.292, n.8, p. 404–411,2000.
3 GERALDE,M. C.et al.Pneumonia treatment by photodynamic therapy with extracorporeal illumination : an experimental model. Physiological Reports, v.5, n.5, p. 13190, 2017.
| Apresentação do trabalho acadêmico para o público geral | Não |
|---|---|
| Subárea | Física Aplicada |
